Natural Heartworm Prevention Without Pills

natural heartworm prevention
Post At A Glance

Some vets tell dog owners that heartworm medicine is too dangerous to use. Does that surprise you?

Holistic veterinarian Glen Dupree DVM didn’t want his patients taking heartworm medicine. Dr Dupree found that a strong immune system was enough to protect his dogs from heartworm. And he also knew that giving dogs neurotoxic drugs every month would harm that immune system.

“I assume my dogs have heartworms,” said Dr Dupree. “But there’s a big difference between heartworms and heartworm disease.” 

And that difference is a fully functioning immune system.

Do Dogs Need Heartworm Medicine?

There are many holistic vets who don’t recommend using heartworm medicine. But the pro-health approach … using natural heartworm prevention … isn’t all that popular (yet).

When you think of the immune system, you probably think about protection from diseases like parvo or kennel cough … or cancer. But your dog’s immune system also protects his body from parasites like heartworms.

A well-tuned immune system is the difference between a few heartworms that your dog’s body keeps in check … and a large heartworm load that affects your dog’s health. That’s what Dr Dupree was talking about.  So a big part of protecting your dog from heartworm is protecting his immune system.  We’ll talk about that a bit later.

The Risks Of Heartworm Drugs

Heartworm meds are neurotoxins. They kill larvae is by paralyzing them. So it’s no wonder that they can also damage your dog. In the side effects below, you’ll see they often include neurological problems … like ataxia, tremors, convulsions, or seizures. 

And that’s just in the short term. Nobody really knows the long-term risks of heartworm meds. Because they haven’t tested the effects of giving them for several months every year, for your dog’s whole life.

So the best guess we have is the adverse reactions that occur right after taking heartworm meds. 

Here are some reported side effects of common heartworm medications for dogs …

HEARTGARD And TriHeartPlus (ivermectin)
Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

INTERCEPTOR (milbemycin oxime)
The above reactions plus weakness.

SENTINEL (milbemycin oxime)
Vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation and weakness.

REVOLUTION® (selamectin), Topical Parasiticide For Dogs and Cats
Vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors, pruritis, urticaria, erythema, ataxia, fever. There have been some reports of death and seizures in dogs.

ProHeart 6 and Proheart 12
These are injectable drugs that last for 6 or 12 months. Severe allergic reactions (anaphylaxis): facial swelling, itching, difficulty breathing, collapse; lethargy (sluggishness); not eating or losing interest in food; any change in activity level; seizures; vomiting and/or diarrhea (with and without blood); weight loss; pale gums, increased thirst or urination, weakness, bleeding, bruising; rare instances of death. 

The maker withdrew ProHeart 6 from the market in 2004 because of deaths. But they’ve brought it back. And now they’ve introduced ProHeart 12 too! The really scary thing about these injectables is that if your dog has a reaction, you can’t just stop giving them. The drugs are in his body for 6 or 12 months. 

And of course, if your dog gets side effects from the meds, it’ll weaken his immune system too. And a weaker immune system makes him more susceptible to all diseases … including heartworms.

RELATED: Read more about the dangers of heartworm medication …

There’s another problem with heartworm meds …

Heartworms Are Becoming Resistant To Meds
You might have heard that heartworms are becoming resistant to heartworm meds. The more we use the drugs, the less effective they become. In the US, more and more dogs each year are getting heartworm while on the meds.

So, do dogs need heartworm medicine year-round? The AHS solution is to drug resistant heart worms is to recommend giving meds year-round. This doesn’t seem logical. The heartworms are becoming resistant to the drugs … and the solution is to give more drugs? You’d think that giving more drugs would increase the problem, not reduce it. The time dogs need protection from heartworms is during mosquito season, when mosquitoes might bite them and transmit the disease.

How Do Dogs Get Heartworms?

Let’s be very clear about one thing. The ONLY way your dog can get heart worms is from a mosquito bite. He can’t catch heartworms from another dog … or even another animal. 

We’ll go over the process of heartworm infection in a bit. But first, let’s clear up another confusing detail ….  

The Difference Between Heartworm Microfilariae And Larvae
People (even some vets) often use these words interchangeably. So, it’s no wonder we’re confused. Because they’re not the same. In fact, microfilariae and larvae are both young heartworms … but in different stages of development

Microfilariae are heartworm babies … and larvae are the “toddlers” that grow up from those babies. They grow from microfilariae to larvae inside mosquitoes …

  • When adult heartworms breed inside an animal, they create microfilariae. 
  • When a mosquito bites an infected animal, it picks up the microfilariae. 
  • After the mosquito picks up the microfilariae, they grow into larvae in the mosquito

Keep that difference in mind as we talk about how mosquitoes give your dog heartworm. Here’s the sequence of events …

  1. The mosquito picks up heartworm microfilariae by biting a heartworm-infected animal. 
  2. Microfilariae grow into larvae in the mosquito. 
  3. The mosquito with heartworm larvae bites your dog, leaving larvae in him.
  4. Over about 6-7 months, the larvae can grow into adult heartworms in your dog.
  5. Eventually, the adult heartworms start breeding … creating microfilariae. 

If you’d like a visual aid to explain the process, the American Heartworm Society has quite a good diagram

It’s useful to understand how heartworm infections happen, so you can protect your dog from heartworm without toxic drugs. 

Natural Heartworm Prevention For Dogs

Yes, it’s possible to protect your dog without harmful drugs. Even in places where mosquitoes are bad. It might not be as simple as giving that tasty heartworm chew every month … but it’s a lot safer for your dog! 

Because of the way heart worms develop, the goal of heartworm meds is to kill the larvae before they grow up. But your dog’s own immune system can do that … without drugs. That’s the reason for focusing on the immune system … it’s the first step in avoiding heartworm disease. 

#1 Support Your Dog’s Immune System

Your healthy dog’s own immune system can prevent heartworm disease. Yes, that’s heartworm disease, not heartworms. They’re not the same thing, as Dr Dupree said. 

It means … your dog could have heartworms in his body. But they don’t have to make him sick. 

Think about wild dogs like wolves, coyotes or foxes. These animals are outdoors 24/7. So they’re much more likely to get mosquito bites than domestic dogs who live mainly indoors. Wild dogs might have heartworms … but research shows they don’t get heartworm disease. And they don’t die of heartworms. 

Wild dogs are healthier because they eat natural diets. And they’re not exposed to drugs and toxins like domestic dogs. 

So you can strengthen your domestic dog’s health with a natural lifestyle too. That means …

  • Feed a natural, raw meat-based, whole food diet (not kibble)
  • Minimize vaccines
  • Use natural remedies instead of pharmaceutical drugs
  • Use natural flea and tick prevention
  • Don’t use chemicals in your home and yard
  • Give your dog fresh spring or filtered water
  • Give him plenty of exercise

Even if you aren’t already doing these things, jt’s not too late to start. Your dog won’t develop a robust immune system overnight. It’ll take time … but you can help him along by giving some immune boosting herbs and supplements. 

RELATED: Read about dog immune system boosters that work …

#2 Avoid Mosquito Bites

If you live somewhere with a lot of mosquitoes, try to keep them away from your dog. 

  • Avoid standing water in your yard or on walks
  • Keep your dog indoors at dawn and dusk or when mosquitoes are most active
  • Avoid swampy mosquito breeding areas on walks
  • Use natural mosquito repellents to keep the bugs away
  • Feed fresh garlic to help repel mosquitoes

Steps #1 and #2 will keep most healthy dogs heartworm free. But you may want a layer of extra protection, especially if you live in a high mosquito area … or your dog is new to the natural lifestyle!

#3 Use Herbal Heartworm Protection

There are different ways to do this. 

Buy A Ready-Made Herbal Blend

There are some pre-made herbal heartworm products you can buy.  As you search, be aware their websites usually won’t directly say they prevent heartworms. That’s because the FDA won’t let manufacturers make that claim for natural products. So they have to be a bit subtle in the language they use to describe their product. They’ll say things like … 

  • Supports normal heart function
  • Promotes healthy blood circulation 
  • Helps detox foreign contaminates
  • For use during mosquito season

This means you might have to call the company to find out if their product really protects from heartworm. They’ll be more open on the phone. 

You may see ingredients like …

  • Hawthorn (a heart-strengthening herb that helps circulation)
  • Dandelion leaves (help with detox)
  • Garlic (anti-parasitic, immune support and insect repellent)
  • Neem (immune support, insect repellent)
  • Wormwood (antiparasitic)
  • Black Walnut (antiparasitic)
  • Black seed (antiparasitic

DNM RECOMMENDS: Amber Naturalz offers HWF/Clean Heart, a natural blend of herbs to strengthen and detox the heart, supporting normal heart function. Buy HWF now …

Use Individual Herbs
For this option it’s best to work with a holistic vet or herbalist. A professional can recommend a protocol to protect your dog from heartworm. The advantage of this approach is that it can be tailored to your dog’s individual needs. 

Your herbalist may recommend various combinations of herbs. They may include herbs like …

  • Wormwood (antiparasitic – use only with professional guidance)
  • Hawthorn (strengthens heart function)
  • Ginger (supports heart disease risk factors)
  • Thyme (supports immunity, repels mosquitoes)
  • Garlic (supports heart health, repels insects)
  • Peppermint (bug repellent)
  • Cinnamon (for heart and neurological health)
  • Cloves (antiparasitic)
  • Dan shen (supports cardiovascular health)
  • Medicinal mushrooms (boost immunity)
  • CoQ10 (heart-strengthening supplement)

You can find a holistic veterinarian who uses western herbs in their practice. Search at and select Western Herbs as the Modality.

Extra Herbal Support|
Herbalists Greg Tilford and Mary Wulff recommend giving echinacea if you’re going into high risk areas. Echinacea supports your dog’s immune system. You can give most dogs 12-25 drops of tincture 3 times a day, for 3 days before and 3 days after your outing. 

Caution: Don’t use echinacea full time. Most experts say it’s best used when the immune system needs extra support. 

There’s one other thing you can do to protect your dog … even if you don’t give any drugs or herbal remedies.

#4 Test For Heartworm More Often

Most vets recommend testing for heartworm once a year, in spring. But if you test your dog for heartworm more often … you’ll find an infection sooner. And that means you can start treating him at an earlier stage.  

How Heartworm Tests Work

There are 3 different types of heartworm tests. 

Antigen Test
The regular test your vet does is an antigen test. Here are the shortcomings of this test. 

  • It can only identify adult female heartworms. That’s why your vet says it takes heartworms 6 months to show up on testing. 
  • Heartworm antigen can be in the blood within 5 months. But most dogs won’t show antigen until 7 months after infection.
  • These tests also may not pick up a low worm burden. If your dog only has one or two female worms, the test has a 30-40% false negative rate. 
  • Some dogs won’t show antibody at all due to “antigen-antibody complexes” in the blood. 

So that’s why your vet may also do a microfilariae test. 

Microfilariae Test
This test will show if there are microfilariae in your dog’s system. And official recommendations have changed. In the past, vets only did it if the antigen test was positive or weak-positive.  

The AHS now recommends doing the microfilariae test annually. This avoids false negatives on the antigen test. A positive microfilariae test confirms there are mature heartworms in your dog. And they’re breeding. 

Those two are the tests your vet likely knows about. But there’s a little known, third type of test.

DNA Heartworm Test
This is a DNA test using PCR (polymerase chain reaction) technology. It tests for heartworm DNA in your dog’s blood.

The place to get this test is HealthGene in Canada. The test is the D319 Canine Heartworm (Diofilaria immitis) test on this page.  HealthGene confirms that the test identifies heartworms at all stages. That means it shows microfilariae, larvae and adult heartworms.

You’ll need your vet’s help, because HealthGene won’t work with you directly. Your vet can order the test kits here. Then she’ll have to send the sample to HealthGene in Canada. 

So … which test should you get? And how often?

Which Heartworm Test Should You Choose?

The best choice is the DNA Test by Healthgene … if you can get your vet to help you.

That’s because this test identifies larvae in your dog’s blood. When an infected mosquito first infects your dog, it transmits larvae. The larvae take 6-7 months to grow into adults. Finding the larvae vs adult heartworms means the infection is much easier to treat. So you’d only need to give heartworm meds if your dog’s DNA test was positive for larvae. And not every single month. Or you could use a herbal remedy instead. 

It’s more hassle to get this test. But it’s doable … you just have to talk your vet into it! But if that’s too hard (or expensive) … or you just can’t find a vet to help you … 

Next best is the regular antigen test your vet does. But you’ll need to do it more often than once a year.

Your vet may insist there’s no point in testing more often than once a year. That’s because they know the test won’t be positive until 6 or 7 months after infection. So they test in spring, before prescribing heartworm meds for the next season. 

But wouldn’t it be better to know if your dog’s positive sooner rather than later? Your vet waits until several months after the end of mosquito season. But if peak mosquito season where you live is during summer months (June through August) … your dog could test positive as early as December or January. Why wait till spring to find out?

It could be worth a couple of extra tests starting 6 months after the beginning of mosquito season wherever you live. And then, if your dog is positive, you can start treating him a few months sooner … before more adults develop.


The microfilariae test is just a way to confirm the accuracy of the antigen test. So if you want to be more confident, you could do it alongside the antigen test.

So in summary, here’s why I don’t give my dogs heartworm meds:

  • Heartworms are becoming resistant. Even dogs on meds are getting them.
  • Heartworm meds contain toxic ingredients. These toxins make my dogs more likely to get heartworms and other parasites.
  • Heartworm meds can be replaced with herbal remedies.
  • Regular testing can help you identify infections earlier.

Perhaps you’ll consider avoiding these drugs too. Your vet may disapprove. But now you have some information to help you with that discussion! 


Knight DH et al. Seasonality of heartworm infection and implications for chemoprophylaxls in the united states. Clinical Techniques In Small Animal Practice. 1998 May:13(2).

Adrian J Wooltenholme et al. The emergence of macrolycyclic lactone resistance in the canine heartworm, Dirofilaria immitis. 8 May 2015

Catherine Bourguinat et al. Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance. Veterinary Parasitology, Volume 210, Issues 3–4, 2015, Pages 167-178.


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